| First Author | Smith-Cortinez N | Year | 2021 |
| Journal | Front Mol Neurosci | Volume | 14 |
| Pages | 729625 | PubMed ID | 34675775 |
| Mgi Jnum | J:312688 | Mgi Id | MGI:6785943 |
| Doi | 10.3389/fnmol.2021.729625 | Citation | Smith-Cortinez N, et al. (2021) LGR5-Positive Supporting Cells Survive Ototoxic Trauma in the Adult Mouse Cochlea. Front Mol Neurosci 14:729625 |
| abstractText | Sensorineural hearing loss is mainly caused by irreversible damage to sensory hair cells (HCs). A subgroup of supporting cells (SCs) in the cochlea express leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), a marker for tissue-resident stem cells. LGR5+ SCs could be used as an endogenous source of stem cells for regeneration of HCs to treat hearing loss. Here, we report long-term presence of LGR5+ SCs in the mature adult cochlea and survival of LGR5+ SCs after severe ototoxic trauma characterized by partial loss of inner HCs and complete loss of outer HCs. Surviving LGR5+ SCs (confirmed by GFP expression) were located in the third row of Deiters' cells. We observed a change in the intracellular localization of GFP, from the nucleus in normal-hearing to cytoplasm and membrane in deafened mice. These data suggests that the adult mammalian cochlea possesses properties essential for regeneration even after severe ototoxic trauma. |
