| First Author | Goeritzer M | Year | 2023 |
| Journal | Int J Mol Sci | Volume | 24 |
| Issue | 4 | PubMed ID | 36834530 |
| Mgi Jnum | J:352283 | Mgi Id | MGI:7441066 |
| Doi | 10.3390/ijms24043116 | Citation | Goeritzer M, et al. (2023) Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice. Int J Mol Sci 24(4) |
| abstractText | Monoglyceride lipase (MGL) hydrolyzes monoacylglycerols (MG) to glycerol and one fatty acid. Among the various MG species, MGL also degrades 2-arachidonoylglycerol, the most abundant endocannabinoid and potent activator of the cannabinoid receptors 1 and 2. We investigated the consequences of MGL deficiency on platelet function using systemic (Mgl(-/-)) and platelet-specific Mgl-deficient (platMgl(-/-)) mice. Despite comparable platelet morphology, loss of MGL was associated with decreased platelet aggregation and reduced response to collagen activation. This was reflected by reduced thrombus formation in vitro, accompanied by a longer bleeding time and a higher blood volume loss. Occlusion time after FeCl(3)-induced injury was markedly reduced in Mgl(-/-) mice, which is consistent with contraction of large aggregates and fewer small aggregates in vitro. The absence of any functional changes in platelets from platMgl(-/-) mice is in accordance with lipid degradation products or other molecules in the circulation, rather than platelet-specific effects, being responsible for the observed alterations in Mgl(-/-) mice. We conclude that genetic deletion of MGL is associated with altered thrombogenesis. |
