| First Author | Leyns CEG | Year | 2019 |
| Journal | Nat Neurosci | Volume | 22 |
| Issue | 8 | Pages | 1217-1222 |
| PubMed ID | 31235932 | Mgi Jnum | J:281622 |
| Mgi Id | MGI:6378367 | Doi | 10.1038/s41593-019-0433-0 |
| Citation | Leyns CEG, et al. (2019) TREM2 function impedes tau seeding in neuritic plaques. Nat Neurosci 22(8):1217-1222 |
| abstractText | Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer's disease. Here we show that germline knockout of Trem2 or the TREM2(R47H) variant reduces microgliosis around amyloid-beta plaques and facilitates the seeding and spreading of neuritic plaque tau aggregates. These findings demonstrate a key role for TREM2 and microglia in limiting the development of peri-plaque tau pathologies. |
