| First Author | Han C | Year | 2016 |
| Journal | Biochem Biophys Res Commun | Volume | 469 |
| Issue | 4 | Pages | 897-902 |
| PubMed ID | 26713362 | Mgi Jnum | J:233164 |
| Mgi Id | MGI:5780907 | Doi | 10.1016/j.bbrc.2015.12.057 |
| Citation | Han C, et al. (2016) Modified sympathetic nerve regulation in AKAP5-null mice. Biochem Biophys Res Commun 469(4):897-902 |
| abstractText | Genetic analyses have revealed an important association between A-kinase anchoring proteins (AKAPs) and the intracellular calcium modulating system. AKAP5, also known as AKAP79/150, is an anchoring protein between PKA and voltage-dependent calcium channels, ryanodine receptor-2, phospholamban and other molecules. The aim of the present study was to elucidate the physiological importance of AKAP5 in the creation of cardiac rhythm using AKAP5-null mice. ECG analysis showed a normal sinus rhythm and a decreased responsiveness to isoproterenol in AKAP5-null mice compared with wild-type mice. Analysis of heart rate variability revealed that the R-R interval was unstable in AKAP5-null mutants and that the low-frequency components had decreased, indicating that the tonus of the sympathetic nervous system was affected. Furthermore, the atrium of the AKAP5-null mice showed a decreased positive inotropic response to isoproterenol, indicating the involvement of AKAP5 in a PKA-dependent pathway. Thus, our present study revealed that AKAP5 plays a significant role in the regulation of sympathetic nerve activities. |
