| First Author | Mitsutake S | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 9 | Pages | 1300-5 |
| PubMed ID | 22465662 | Mgi Jnum | J:183624 |
| Mgi Id | MGI:5319015 | Doi | 10.1016/j.febslet.2012.03.032 |
| Citation | Mitsutake S, et al. (2012) Ceramide kinase deficiency improves diet-induced obesity and insulin resistance. FEBS Lett 586(9):1300-5 |
| abstractText | Ceramide kinase (CERK) is an enzyme that phosphorylates ceramide to produce ceramide 1-phosphate. Recently, evidence has emerged that CERK has a role in inflammatory signaling of immune cells. Since obesity is accompanied by chronic, low-grade inflammation, we examined whether CERK might be involved using CERK-null mice. We determined that CERK deficiency suppresses diet-induced increases in body weight, and improves glucose intolerance. Furthermore, we demonstrated that CERK deficiency attenuates MCP-1/CCR2 signaling in macrophages infiltrating the adipose tissue, resulting in the suppression of inflammation in adipocytes, which might otherwise lead to obesity and diabetes. |
