| First Author | Guerder S | Year | 1995 |
| Journal | J Immunol | Volume | 155 |
| Issue | 11 | Pages | 5167-74 |
| PubMed ID | 7594526 | Mgi Jnum | J:127704 |
| Mgi Id | MGI:3764678 | Doi | 10.4049/jimmunol.155.11.5167 |
| Citation | Guerder S, et al. (1995) B7 costimulation is necessary for the activation of the lytic function in cytotoxic T lymphocyte precursors. J Immunol 155(11):5167-74 |
| abstractText | B7-CD28 costimulation is essential for the activation of CD4+ T helper cells, mainly by regulating IL-2 and other cytokine production. The requirement for this costimulatory pathway in the activation of CD8+ T cells, however, is still poorly understood. Here we analyzed the role of B7-CD28 costimulation in the differentiation of Ag-specific CTL precursor. We found that the activation of not only IL-2 production but also cytotoxic function in CD8 T cells requires B7 costimulation. The costimulatory signal, which cannot be replaced by exogenous IL-2, is directly implicated in the activation of the lytic machinery in CD8 T cells. Moreover, B7-CD28 costimulation appears to play a critical role in the accumulation of mRNA encoding at least one of the granzymes required for cytolytic function, granzyme B or CTLA-1. The production of IFN-gamma by CD8 T cells, however, does not appear to require costimulation. |
