| First Author | Jin J | Year | 2018 |
| Journal | Biochem Biophys Res Commun | Volume | 503 |
| Issue | 3 | Pages | 1594-1598 |
| PubMed ID | 30054043 | Mgi Jnum | J:272269 |
| Mgi Id | MGI:6280241 | Doi | 10.1016/j.bbrc.2018.07.086 |
| Citation | Jin J, et al. (2018) Distinct function of miR-17-92 cluster in the dorsal and ventral adult hippocampal neurogenesis. Biochem Biophys Res Commun 503(3):1594-1598 |
| abstractText | It has been known that the dorsal and ventral areas of the dentate gyrus in the hippocampus have distinct roles in memory and mood behaviors. We previously reported that microRNA miR-17-92 regulates adult hippocampal neurogenesis and mood disorders. Here, we suggest that the miR-17-92 cluster is highly expressed in the ventral than the dorsal dentate gyrus in the adult mouse hippocampus. Deletion of miR-17-92 in the adult hippocampus only affects development of neural progenitors in the ventral dentate gyrus, and miR-17-92 knockout mice have no defects in memory functions. Our results suggest that regional expression of miR-17-92 in the dentate gyrus is associated with their distinct functions in hippocampal neurogenesis and related behaviors. |
