| First Author | Bharadwaj MS | Year | 2014 |
| Journal | Redox Biol | Volume | 2 |
| Pages | 1008-15 | PubMed ID | 25460737 |
| Mgi Jnum | J:226869 | Mgi Id | MGI:5698776 |
| Doi | 10.1016/j.redox.2014.08.006 | Citation | Bharadwaj MS, et al. (2014) Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice. Redox Biol 2C:1008-1015 |
| abstractText | Inner mitochondrial membrane peptidase 2-like (IMMP2L) protein is a mitochondrial inner membrane peptidase that cleaves the signal peptide sequences of cytochrome c1 (CYC1) and mitochondrial glycerol phosphate dehydrogenase (GPD2). Immp2l mutant mice show infertility and early signs of aging. It is unclear whether mitochondrial respiratory deficiency underlies this phenotype. Here we show that the intermediate forms of GPD2 and CYC1 have normal expression levels and enzymatic function in Immp2l mutants. Mitochondrial respiration is not diminished in isolated mitochondria and cells from mutant mice. Our data suggest that respiratory deficiency is not the cause of the observed Immp2l mutant phenotypes. |
