| Primary Identifier | MGI:3767397 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Trhde |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| description | No overt phenotype was noted in homozygous mutant mice, although these animals exhibited higher night time wheel running activity under normal light/dark cycles, and reduced activity in constant light. Reporter expression in mutant mice suggests that protein in wild-type mice would be highly expressed in photosensitive tissues. |
| molecularNote | Insertion of a bicistronic reporter construct into exon 1 inactivated the gene and brought both lacZ and PLAP under control of the endogenous promoter. The construct contains a bacterial beta-galactosidase open reading frame followed by a retroviral internal ribosome entry site (IRES) element, a human PLAP open reading frame, and a floxed neomycin resistance gene (lacZ-IRES-PLAP-loxP-neo-loxP). In heterozygous mice, lacZ is expressed in the cerebral cortex and in the hippocampal formation of Ammon's horn. |
