| First Author | Herda S | Year | 2012 |
| Journal | Immunity | Volume | 37 |
| Issue | 5 | Pages | 854-66 |
| PubMed ID | 23084031 | Mgi Jnum | J:190688 |
| Mgi Id | MGI:5449472 | Doi | 10.1016/j.immuni.2012.07.012 |
| Citation | Herda S, et al. (2012) The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-gamma and granzyme A in T cells. Immunity 37(5):854-66 |
| abstractText | Immunological control of infections or tumors depends on the release of effector cytokines and polarized secretion of cytotoxic granules from T cells and natural killer cells. Here we show that the sorting receptor Sortilin controlled both processes. In murine Sortilin-deficient cytotoxic T lymphocytes, regulated secretion of granzyme A and cytotoxic killing was enhanced and correlated with increased vesicle-associated membrane protein 7 availability. In contrast, loss of Sortilin reduced the release of interferon-gamma upon infections and in autoimmune colitis. Exit of interferon-gamma from the Golgi apparatus required the presence of Sortilin. Furthermore, we tracked the transport route of interferon-gamma beyond this Sortilin-dependent Golgi to early endosome step. In wild-type T cells, trafficking of interferon-gamma from the endosomal sorting platform to the plasma membrane proceeded independently of recycling endosomes, and interferon-gamma remained excluded from late endosomes. Our results suggest that Sortilin modulates systemic immune responses through exocytic sorting of immunological effector molecules. |
