| First Author | Cho HK | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 5 | Pages | 733-9 |
| PubMed ID | 24462680 | Mgi Jnum | J:206663 |
| Mgi Id | MGI:5551665 | Doi | 10.1016/j.febslet.2014.01.017 |
| Citation | Cho HK, et al. (2014) Hepatitis B virus X increases immune cell recruitment by induction of chemokine SDF-1. FEBS Lett 588(5):733-9 |
| abstractText | Hepatitis B virus X protein is a major factor in the HBV-induced disease developments. Stromal cell-derived factor-1 is a small cytokine that is strongly chemotactic for lymphocytes. We explored the role of HBx on recruitment of HBV-induced virus-nonspecific immune cells into liver. Immune cell recruitment and SDF-1 expression level significantly increased in livers of HBx-transgenic mice and X-box binding protein-1 significantly increased SDF-1 gene expression. Finally, we confirmed that immune cell recruitment into liver tissues of HBx-TG mice was diminished by a chemokine receptor antagonist. Therefore, HBx increases ER stress-dependent SDF-1 expression and induces HBV-induced immune cell recruitment into liver. |
