| First Author | Cogut V | Year | 2024 |
| Journal | J Alzheimers Dis | Volume | 98 |
| Issue | 3 | Pages | 925-940 |
| PubMed ID | 38517786 | Mgi Jnum | J:355490 |
| Mgi Id | MGI:7748855 | Doi | 10.3233/JAD-231117 |
| Citation | Cogut V, et al. (2024) Caloric Restriction Improves Spatial Learning Deficits in Tau Mice. J Alzheimers Dis 98(3):925-940 |
| abstractText | BACKGROUND: Caloric restriction (CR) has been recognized for its benefits in delaying age-related diseases and extending lifespan. While its effects on amyloid pathology in Alzheimer's disease (AD) mouse models are well-documented, its effects on tauopathy, another hallmark of AD, are less explored. OBJECTIVE: To assess the impact of a short-term 30% CR regimen on age-dependent spatial learning deficits and pathological features in a tauopathy mouse model. METHODS: We subjected male PS19 tau P301S (hereafter PS19) and age-matched wildtype mice from two age cohorts (4.5 and 7.5 months old) to a 6-week 30% CR regimen. Spatial learning performance was assessed using the Barnes Maze test. Tau pathology, neuroinflammation, hippocampal cell proliferation, and neurogenesis were evaluated in the older cohort by immunohistochemical staining and RT-qPCR. RESULTS: CR mitigated age-dependent spatial learning deficits in PS19 mice but exhibited limited effects on tau pathology and the associated neuroinflammation. Additionally, we found a decrease in hippocampal cell proliferation, predominantly of Iba1+ cells. CONCLUSIONS: Our findings reinforce the cognitive benefits conferred by CR despite its limited modulation of disease pathology. Given the pivotal role of microglia in tau-driven pathology, the observed reduction in Iba1+ cells under CR suggests potential therapeutic implications, particularly if CR would be introduced early in disease progression. |
