| First Author | Imai Y | Year | 2007 |
| Journal | Neurosci Res | Volume | 59 |
| Issue | 4 | Pages | 413-25 |
| PubMed ID | 17889953 | Mgi Jnum | J:128745 |
| Mgi Id | MGI:3767931 | Doi | 10.1016/j.neures.2007.08.005 |
| Citation | Imai Y, et al. (2007) Pael receptor is involved in dopamine metabolism in the nigrostriatal system. Neurosci Res 59(4):413-25 |
| abstractText | Pael receptor (Pael-R) has been identified as one of the substrates of Parkin, a ubiquitin ligase responsible for autosomal recessive juvenile Parkinsonism (AR-JP). When Parkin is inactivated, unfolded Pael-R accumulates in the endoplasmic reticulum and results in neuronal death by unfolded protein stress, suggesting that Pael-R has an important role in the pathogenesis of AR-JP. Here we report the analyses on Pael-R-deficient (KO) and Pael-R-transgenic (Tg) mice. The striatal dopamine (DA) level of Pael-R KO mice was only 60% of that in normal mice, while in Pael-R Tg mice, striatal 3,4-dihydroxyphenylacetic acid (DOPAC) as well as vesicular DA content increased. Moreover, the nigrostriatal dopaminergic neurons of Pael-R Tg mice are more vulnerable to Parkinson's disease-related neurotoxins while those of Pael-R KO mice are less. These results strongly suggest that the Pael-R signal regulates the amount of DA in the dopaminergic neurons and that excessive Pael-R expression renders dopaminergic neurons susceptible to chronic DA toxicity. |
