| First Author | Anderson LJ | Year | 2008 |
| Journal | J Gen Virol | Volume | 89 |
| Issue | Pt 7 | Pages | 1563-8 |
| PubMed ID | 18559925 | Mgi Jnum | J:278468 |
| Mgi Id | MGI:6142289 | Doi | 10.1099/vir.0.2008/001461-0 |
| Citation | Anderson LJ, et al. (2008) EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathway. J Gen Virol 89(Pt 7):1563-8 |
| abstractText | Latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV) provides developmental and survival signals that mimic those of a B-cell receptor (BCR). Expression of LMP2A during B-cell development results in the ability of B cells to exit the bone marrow in the absence of a BCR and persist in the periphery, where they would normally undergo apoptosis. This study extends the current knowledge of LMP2A function by examining the growth properties of bone marrow B cells from TgE LMP2A mice. Despite the lack of pre-BCR expression, bone marrow B cells from TgE LMP2A mice proliferate and survive in low concentrations of interleukin 7, similar to wild-type cells. Constitutive phosphorylation of ERK/MAPK and PI3K/Akt in TgE LMP2A bone marrow B cells is also reminiscent of signalling through the pre-BCR, altogether demonstrating that LMP2A provides a pre-BCR-like signal to developing B cells. |
