| First Author | McHugh KM | Year | 2014 |
| Journal | Pediatr Nephrol | Volume | 29 |
| Issue | 4 | Pages | 645-50 |
| PubMed ID | 24276861 | Mgi Jnum | J:292558 |
| Mgi Id | MGI:6450408 | Doi | 10.1007/s00467-013-2658-6 |
| Citation | McHugh KM (2014) Megabladder mouse model of congenital obstructive nephropathy: genetic etiology and renal adaptation. Pediatr Nephrol 29(4):645-50 |
| abstractText | Congenital obstructive nephropathy remains one of the leading causes of chronic renal failure in children. The direct link between obstructed urine flow and abnormal renal development and subsequent dysfunction represents a central paradigm of urogenital pathogenesis that has far-reaching clinical implications. Even so, a number of diagnostic, prognostic, and therapeutic quandaries still exist in the management of congenital obstructive nephropathy. Studies in our laboratory have characterized a unique mutant mouse line that develops in utero megabladder, variable hydronephrosis, and progressive renal failure. Megabladder mice represent a valuable functional model for the study of congenital obstructive nephropathy. Recent studies have begun to shed light on the genetic etiology of mgb (-/-) mice as well as the molecular pathways controlling disease progression in these animals. |
