| First Author | Pai EL | Year | 2019 |
| Journal | Cell Rep | Volume | 26 |
| Issue | 5 | Pages | 1157-1173.e5 |
| PubMed ID | 30699346 | Mgi Jnum | J:288455 |
| Mgi Id | MGI:6432276 | Doi | 10.1016/j.celrep.2019.01.031 |
| Citation | Pai EL, et al. (2019) Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function. Cell Rep 26(5):1157-1173.e5 |
| abstractText | Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV(+)) and somatostatin (SST(+)) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST(+) cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development. |
