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Publication : Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells.

First Author  Adams NM Year  2019
Journal  Immunity Volume  50
Issue  6 Pages  1381-1390.e5
PubMed ID  31103381 Mgi Jnum  J:282419
Mgi Id  MGI:6380860 Doi  10.1016/j.immuni.2019.04.009
Citation  Adams NM, et al. (2019) Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells. Immunity 50(6):1381-1390.e5
abstractText  The process of affinity maturation, whereby T and B cells bearing antigen receptors with optimal affinity to the relevant antigen undergo preferential expansion, is a key feature of adaptive immunity. Natural killer (NK) cells are innate lymphocytes capable of "adaptive" responses after cytomegalovirus (CMV) infection. However, whether NK cells are similarly selected on the basis of their avidity for cognate ligand is unknown. Here, we showed that NK cells with the highest avidity for the mouse CMV glycoprotein m157 were preferentially selected to expand and comprise the memory NK cell pool, whereas low-avidity NK cells possessed greater capacity for interferon-gamma (IFN-gamma) production. Moreover, we provide evidence for avidity selection occurring in human NK cells during human CMV infection. These results delineate how heterogeneity in NK cell avidity diversifies NK cell effector function during antiviral immunity, and how avidity selection might serve to produce the most potent memory NK cells.
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