| First Author | Kandel P | Year | 2022 |
| Journal | Proc Natl Acad Sci U S A | Volume | 119 |
| Issue | 13 | Pages | e2023784119 |
| PubMed ID | 35333654 | Mgi Jnum | J:349569 |
| Mgi Id | MGI:7276119 | Doi | 10.1073/pnas.2023784119 |
| Citation | Kandel P, et al. (2022) Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis. Proc Natl Acad Sci U S A 119(13):e2023784119 |
| abstractText | SignificanceAdult hippocampal neurogenesis underpins learning, memory, and mood but diminishes with age and certain illnesses. The orphan nuclear receptor TLX/NR2E1 regulates neural stem and progenitor cell self-renewal and proliferation, but its orphan status has hindered its utilization as a therapeutic target to modulate adult neurogenesis. Here, we deorphanize TLX and report that oleic acid is an endogenous, metabolic ligand of TLX. These findings open avenues for future therapeutic modulation of TLX to counteract cognitive and mental decline in aging and diseases associated with decreased neurogenesis. |
