| Primary Identifier | MGI:3778906 | Allele Type | Targeted |
| Gene | Tfrc | Transmission | Germline |
| Strain of Origin | 129S4/SvJae | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Exon 17 was replaced with one in which a nucleotide susbtitution resulted in an amino acid substitution of alanine for leucine at position 622 (L622A). A floxed neo cassette was also inserted downstream of exon 17 but was subsequently removed by germ-line, cre-mediated recombination. This mutation prevents binding to Hfe but does not interfer with binding to Tf. |
