| First Author | Druckenbrod NR | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 5866 |
| PubMed ID | 33203842 | Mgi Jnum | J:301359 |
| Mgi Id | MGI:6504450 | Doi | 10.1038/s41467-020-19521-2 |
| Citation | Druckenbrod NR, et al. (2020) Neuronal processes and glial precursors form a scaffold for wiring the developing mouse cochlea. Nat Commun 11(1):5866 |
| abstractText | In the developing nervous system, axons navigate through complex terrains that change depending on when and where outgrowth begins. For instance, in the developing cochlea, spiral ganglion neurons extend their peripheral processes through a growing and heterogeneous environment en route to their final targets, the hair cells. Although the basic principles of axon guidance are well established, it remains unclear how axons adjust strategies over time and space. Here, we show that neurons with different positions in the spiral ganglion employ different guidance mechanisms, with evidence for both glia-guided growth and fasciculation along a neuronal scaffold. Processes from neurons in the rear of the ganglion are more directed and grow faster than those from neurons at the border of the ganglion. Further, processes at the wavefront grow more efficiently when in contact with glial precursors growing ahead of them. These findings suggest a tiered mechanism for reliable axon guidance. |
