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Publication : Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume.

First Author  Conductier G Year  2013
Journal  Nat Neurosci Volume  16
Issue  7 Pages  845-7
PubMed ID  23708141 Mgi Jnum  J:203353
Mgi Id  MGI:5526884 Doi  10.1038/nn.3401
Citation  Conductier G, et al. (2013) Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. Nat Neurosci 16(7):845-7
abstractText  Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
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