| First Author | Tchang VS | Year | 2013 |
| Journal | Mol Immunol | Volume | 56 |
| Issue | 4 | Pages | 683-92 |
| PubMed ID | 23933558 | Mgi Jnum | J:202346 |
| Mgi Id | MGI:5518510 | Doi | 10.1016/j.molimm.2013.05.003 |
| Citation | Tchang VS, et al. (2013) Diverging role for coronin 1 in antiviral CD4(+) and CD8(+) T cell responses. Mol Immunol 56(4):683-92 |
| abstractText | Coronin 1 is a member of the evolutionary conserved WD repeat protein family and is highly expressed in hematopoietic cells. Coronin 1 is essential for Ca(2+) mobilization upon T cell receptor (TCR) stimulation providing a pro-survival signal for naive peripheral T cells. Both in mouse and in human, coronin 1 deficiency is associated with severe T cell lymphopenia. In this work, we have analyzed antiviral T cell-mediated immunity in the presence and absence of coronin 1 in vivo after infection with lymphocytic choriomenigitis virus (LCMV) and vesicular stomatitis virus (VSV) in mice. Despite low peripheral T cell numbers we found that LCMV-specific CD8(+) T cell responses were normal in the absence of coronin 1 and kinetics of LCMV-clearance were similar compared to wild type mice. In contrast, CD4(+) T cell responses were profoundly decreased after LCMV- and VSV-infection. We propose that coronin 1 plays a differential role in CD8(+) versus CD4(+) T cell responses and activation. |
