| First Author | Combaluzier B | Year | 2009 |
| Journal | J Immunol | Volume | 182 |
| Issue | 4 | Pages | 1954-61 |
| PubMed ID | 19201848 | Mgi Jnum | J:144802 |
| Mgi Id | MGI:3831960 | Doi | 10.4049/jimmunol.0801811 |
| Citation | Combaluzier B, et al. (2009) Coronin 1 is essential for IgM-mediated Ca2+ mobilization in B cells but dispensable for the generation of immune responses in vivo. J Immunol 182(4):1954-61 |
| abstractText | Coronin 1 is a leukocyte specific regulator of Ca(2+)-dependent signaling and is essential for the survival of peripheral T lymphocytes, but its role in B cells is unknown. In this study, we show that coronin 1 is essential for intracellular Ca(2+) mobilization and proliferation upon triggering of the BCR. However, the presence of costimulatory signals rendered coronin 1 dispensable for B cell signaling, consistent with the generation of normal immune responses against a variety of Ags in coronin 1-deficient mice. We conclude that coronin 1, while being essential for T cell function and survival, is dispensable for B cell function in vivo. |
