| First Author | Combaluzier B | Year | 2009 |
| Journal | J Immunol | Volume | 182 |
| Issue | 5 | Pages | 2745-52 |
| PubMed ID | 19234169 | Mgi Jnum | J:146257 |
| Mgi Id | MGI:3837095 | Doi | 10.4049/jimmunol.0801812 |
| Citation | Combaluzier B, et al. (2009) Chemotaxis and phagocytosis in neutrophils is independent of coronin 1. J Immunol 182(5):2745-52 |
| abstractText | The WD repeat protein family member coronin 1 is exclusively expressed in leukocytes, where it colocalizes with the cortical cytoskeleton. Although initially coronin 1 was believed to regulate F-actin dynamics such as leukocyte motility, phagocytosis, and membrane ruffling, recent work showed that in macrophages, T cells, and B cells, coronin 1 is dispensable for these F-actin dependent processes, instead being involved in the regulation of calcium dependent signaling reactions. In this study, we show that in mice lacking coronin 1 neutrophil populations developed normally, and that coronin 1-deficient neutrophils are fully functional with respect to adherence, membrane dynamics, migration, phagocytosis and the oxidative burst. Therefore, these data argue against a role for coronin 1 in the modulation of F-actin and suggest that coronin 1 is dispensable for neutrophil functioning. |
