| Primary Identifier | MGI:3785748 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Ppp1r3a |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A floxed neo cassette was inserted into intron 3 and exon 4 was replaced with one which contained codons for 6 altered amino acids followed by a premature stop codon as is seen in a human frameshift mutation. Transient cre expression in ES cells was used to remove the neo cassette. Western blot analysis of skeletal muscle confirmed the expression of a truncated protein consisting of 634 amino acid residues. |
