| First Author | Boutant M | Year | 2017 |
| Journal | EMBO J | Volume | 36 |
| Issue | 11 | Pages | 1543-1558 |
| PubMed ID | 28348166 | Mgi Jnum | J:243358 |
| Mgi Id | MGI:5908298 | Doi | 10.15252/embj.201694914 |
| Citation | Boutant M, et al. (2017) Mfn2 is critical for brown adipose tissue thermogenic function. EMBO J 36(11):1543-1558 |
| abstractText | Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act as quality control mechanisms to ensure mitochondrial function and fine-tune cellular bioenergetics. Defective mitofusin 2 (Mfn2) expression and enhanced mitochondrial fission in skeletal muscle are hallmarks of insulin-resistant states. Interestingly, Mfn2 is highly expressed in brown adipose tissue (BAT), yet its role remains unexplored. Using adipose-specific Mfn2 knockout (Mfn2-adKO) mice, we demonstrate that Mfn2, but not Mfn1, deficiency in BAT leads to a profound BAT dysfunction, associated with impaired respiratory capacity and a blunted response to adrenergic stimuli. Importantly, Mfn2 directly interacts with perilipin 1, facilitating the interaction between the mitochondria and the lipid droplet in response to adrenergic stimulation. Surprisingly, Mfn2-adKO mice were protected from high-fat diet-induced insulin resistance and hepatic steatosis. Altogether, these results demonstrate that Mfn2 is a mediator of mitochondria to lipid droplet interactions, influencing lipolytic processes and whole-body energy homeostasis. |
