| Primary Identifier | MGI:3785264 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Elane |
| Transmission | Germline | Strain of Origin | 129X1/SvJ |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 3 was replaced with an exon 3 containing the transition 298G>A that resulted in an amino acid substitution of methionine for valine at position 72 (V72M). A floxed neo was also inserted downstream of exon 5 and subsequently removed by cre-mediated recoombination. This mutation was originally identified in two unrelated patients with severe cognital neutropenia, one of whom had acute myeloid leukemia. |
