| First Author | Richter K | Year | 2013 |
| Journal | Eur J Immunol | Volume | 43 |
| Issue | 3 | Pages | 649-54 |
| PubMed ID | 23348876 | Mgi Jnum | J:193819 |
| Mgi Id | MGI:5469749 | Doi | 10.1002/eji.201242887 |
| Citation | Richter K, et al. (2013) Reversal of chronic to resolved infection by IL-10 blockade is LCMV strain dependent. Eur J Immunol 43(3):649-54 |
| abstractText | Chronic viral infections lead to CD8 T-cell exhaustion, characterized by impaired cytokine secretion. The immune-regulatory cytokine IL-10 promotes chronicity of infection with lymphocytic choriomeningitis virus (LCMV) Clone 13, as absence of IL-10 or blocking of IL-10R during early LCMV Clone 13 infection results in viral clearance. Thus, treatment of humans suffering from chronic viral infections with IL-10 neutralizing or IL-10R blocking antibodies was proposed to boost virus-specific T-cell responses to enhance control or even clear the viral infection. Here we demonstrate that although CD4 and CD8 T cells can produce elevated levels of cytokines in IL-10 mice early after infection compared with WT mice, IL-10 mice cannot clear an infection with the quicker replicating LCMV strain Docile, eventually resulting in T-cell exhaustion. These data suggest that the success of IL-10 blockade to control chronic viral infections may critically depend on the virulence of the infecting strain. |
