| First Author | Potchen NB | Year | 2023 |
| Journal | iScience | Volume | 26 |
| Issue | 12 | Pages | 108504 |
| PubMed ID | 38125026 | Mgi Jnum | J:350854 |
| Mgi Id | MGI:7568530 | Doi | 10.1016/j.isci.2023.108504 |
| Citation | Potchen NB, et al. (2023) Oral tolerance to systemic vaccination remains intact without RORgammat expression in regulatory T cells. iScience 26(12):108504 |
| abstractText | Many promising vaccine candidates and licensed vaccines lead to variable immune responses within humans. Studies suggest that environmental exposures in the gastrointestinal tract could contribute to a reduction in vaccine efficacy via immune tolerance at this site; this is partly achieved by a high abundance of regulatory T cells (Tregs). It is unclear if Treg subsets regulate systemic vaccine responses following oral antigen pre-exposure. Here, we implemented a conditional knock-out mouse model of RORgammat+ Tregs to examine the role of these cells in mediating this process. Following oral exposure to the model antigen ovalbumin (OVA) prior to immunization, we found similar induction of vaccine-induced antibody responses in mice lacking RORgammat expression in Tregs compared to sufficient controls. Use of various adjuvants led to distinct findings. Our data suggest that expression of RORgammat+ within Tregs is not required to regulate tolerance to systemic vaccination following oral antigen exposure. |
