| First Author | Skinner JP | Year | 2014 |
| Journal | PLoS One | Volume | 9 |
| Issue | 2 | Pages | e88997 |
| PubMed ID | 24523948 | Mgi Jnum | J:212942 |
| Mgi Id | MGI:5582557 | Doi | 10.1371/journal.pone.0088997 |
| Citation | Skinner JP, et al. (2014) The miR-17 approximately 92a cluster of microRNAs is required for the fitness of Foxp3+ regulatory T cells. PLoS One 9(2):e88997 |
| abstractText | By genetic inactivation of key microRNA biogenesis enzymes, we and others have previously demonstrated the critical requirement of the microRNA pathway for the differentiation and function of Foxp3(+) regulatory T cells. In this study, we identified members of the miR-17 approximately 92a cluster of microRNAs to be enriched in regulatory T cells. To investigate the function of this microRNA cluster, we deleted the gene specifically in Foxp3(+) cells in mice. We found that miR-17 approximately 92a is required for the fitness of regulatory T cells, and deficiency impacted at the level of apoptosis and proliferation of these cells. This led to a loss of Foxp3(+) cells over time, particularly in competitive settings, and culminated in a range of immunologic perturbations. Thus, miR-17 approximately 92a-target interactions are part of the essential microRNA networks that safeguard the regulatory T cell lineage. |
