| First Author | Stauffer BL | Year | 2006 |
| Journal | J Clin Invest | Volume | 116 |
| Issue | 1 | Pages | 209-16 |
| PubMed ID | 16395406 | Mgi Jnum | J:105362 |
| Mgi Id | MGI:3614896 | Doi | 10.1172/JCI24676 |
| Citation | Stauffer BL, et al. (2006) Soy diet worsens heart disease in mice. J Clin Invest 116(1):209-16 |
| abstractText | We report that dietary modification from a soy-based diet to a casein-based diet radically improves disease indicators and cardiac function in a transgenic mouse model of hypertrophic cardiomyopathy. On a soy diet, males with a mutation in the alpha-myosin heavy chain gene progress to dilation and heart failure. However, males fed a casein diet no longer deteriorate to severe, dilated cardiomyopathy. Remarkably, their LV size and contractile function are preserved. Further, this diet prevents a number of pathologic indicators in males, including fibrosis, induction of beta-myosin heavy chain, inactivation of glycogen synthase kinase 3beta (GSK3beta), and caspase-3 activation. |
