| Primary Identifier | MGI:3795503 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Mirc3 |
| Transmission | Germline | Strain of Origin | (C57BL/6 x 129S4/SvJae)F1 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The Mir106b, Mir93, and Mir25 genes were replaced by an Frt-flanked neomycin cassette. No homozygous mutants are obtained if the neomycin is left in place, but Flp-mediated deletion of neo produces phenotypically normal homozygous mice. Since the Mirn106b-25 cluster resides in the 13th intron of the Mcm7 gene, these results suggest that the neomycin cassette interferes with expression of Mcm7. |
