|  Help  |  About  |  Contact Us

Allele : Th<tm1(cre/Esr1)Nat> tyrosine hydroxylase; targeted mutation 1, Jeremy Nathans

Primary Identifier  MGI:3795871 Allele Type  Targeted
Attribute String  Inducible, Recombinase Gene  Th
Transmission  Germline Strain of Origin  129
Induced With  tamoxifen Is Recombinase  true
Is Wild Type  false
molecularNote  An IRES-creER cassette, a tetracycline resistance gene, and an FRT-flanked neomycin selection marker were all knocked into the 3' UTR of the gene. The neomycin selection marker was removed by crossing to a C57BL/6 background Flp recombinase strain. Flp was then bred out of the line. When crossed with a Tg(CAG-Bgeo/ALPP)1Lbe reporter strain and given tamoxifen, cre expression was detected in a sparse number of dopaminergic neurons in the brain. This is line C2.
  • mutations:
  • Insertion
  • synonyms:
  • TH<iCreER>,
  • Th<tm1(cre/ERT)Nat>,
  • Th<tm1(cre/ERT)Nat>,
  • TH-IRES-creER,
  • TH<iCreER>,
  • TH-IRES-creER line C2,
  • TH<CreER>,
  • Th<tm1(cre/Esr1)Nat>,
  • TH<CreER>,
  • TH-IRES-creER,
  • Th<tm1(cre/Esr1)Nat>,
  • TH-IRES-creER line C2
Quick Links:
 
Quick Links:
 

1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

1 Driven By

Trail: Allele

24 Publication categories

Trail: Allele