| First Author | Li L | Year | 2011 |
| Journal | Cell | Volume | 147 |
| Issue | 7 | Pages | 1615-27 |
| PubMed ID | 22196735 | Mgi Jnum | J:196548 |
| Mgi Id | MGI:5488710 | Doi | 10.1016/j.cell.2011.11.027 |
| Citation | Li L, et al. (2011) The functional organization of cutaneous low-threshold mechanosensory neurons. Cell 147(7):1615-27 |
| abstractText | Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold mechanoreceptors (LTMRs), which are classified as Abeta-, Adelta-, and C-LTMRs. Here, we report genetic labeling of LTMR subtypes and visualization of their relative patterns of axonal endings in hairy skin and the spinal cord. We found that each of the three major hair follicle types of trunk hairy skin (guard, awl/auchene, and zigzag hairs) is innervated by a unique and invariant combination of LTMRs; thus, each hair follicle type is a functionally distinct mechanosensory end organ. Moreover, the central projections of Abeta-, Adelta-, and C-LTMRs that innervate the same or adjacent hair follicles form narrow LTMR columns in the dorsal horn. These findings support a model of mechanosensation in which the activities of Abeta-, Adelta-, and C-LTMRs are integrated within dorsal horn LTMR columns and processed into outputs that underlie the perception of myriad touch sensations. |
