| First Author | Fairfax KA | Year | 2015 |
| Journal | J Leukoc Biol | Volume | 97 |
| Issue | 1 | Pages | 71-8 |
| PubMed ID | 25381386 | Mgi Jnum | J:220192 |
| Mgi Id | MGI:5632447 | Doi | 10.1189/jlb.2A0314-178R |
| Citation | Fairfax KA, et al. (2015) IL-10 regulates Aicda expression through miR-155. J Leukoc Biol 97(1):71-8 |
| abstractText | Aicda is a critical component of antibody class-switching in B cells. In this work, we study the impact of TLR4 activation and IL-10 stimulation on Aicda expression in B cells. Through the global analysis of miRNAs in response to TLR4 activation, in combination with IL-10 stimulation, we identified that IL-10 can suppress TLR4-induced miR-155 expression, an effect that resulted in enhanced Aicda expression. Furthermore, when preventing miR-155 control of Aicda expression, by genetic mutation of its target site in the Aicda mRNA, IL-10 could further potentiate Aicda expression. Given that miR-155 expression is lost, and expression levels of both Aicda and IL-10 are high in diseases, such as Burkitt's lymphoma, our results suggest a stringent and sophisticated control of Aicda by a novel IL-10/miR-155 axis, where the imbalance of IL-10 and/or miR-155 may contribute to disease pathogenesis. |
