| First Author | Bert B | Year | 2008 |
| Journal | Behav Brain Res | Volume | 195 |
| Issue | 1 | Pages | 78-85 |
| PubMed ID | 18396339 | Mgi Jnum | J:140156 |
| Mgi Id | MGI:3811996 | Doi | 10.1016/j.bbr.2008.02.028 |
| Citation | Bert B, et al. (2008) Learning and memory in 5-HT(1A)-receptor mutant mice. Behav Brain Res 195(1):78-85 |
| abstractText | The serotonin 1A (5-HT(1A))-receptor is involved in a wide range of physiological functions, but has also been implicated in the pathophysiology of anxiety disorders and depression. Although the 5-HT(1A)-receptor is one of the best described receptor subtypes of the serotonergic system, its complex distribution pattern, pre- and postsynaptic localisation, and its impact on various neurotransmitters aggravate the attribution of 5-HT(1A)-agonistic effects to behavioural outcomes. The role of 5-HT(1A)-receptors for cognitive processes seems undisputed. However, the exact involvement of pre- and postsynaptic sites remains unexplained. Genetically modified animals are a complementary approach to pharmacological studies for further investigations of the role of the 5-HT(1A)-receptor. Next to 5-HT(1A)-receptor knockout mice, two transgenic mouse lines exist that either overexpress the 5-HT(1A)-receptor transiently or permanently. The latter mouse line stands out due to the fact that a distinct overexpression is primarily found in the outer cortical layers and hippocampus, both projection areas of serotonergic neurons. Here, we discuss the findings obtained from 5-HT(1A)-receptor knockout and overexpressing mice concerning their learning and memory abilities. |
