| First Author | Bert B | Year | 2005 |
| Journal | Neurobiol Learn Mem | Volume | 84 |
| Issue | 1 | Pages | 57-68 |
| PubMed ID | 15936683 | Mgi Jnum | J:128866 |
| Mgi Id | MGI:3768205 | Doi | 10.1016/j.nlm.2005.03.005 |
| Citation | Bert B, et al. (2005) Transient overexpression of the 5-HT1A receptor impairs water-maze but not hole-board performance. Neurobiol Learn Mem 84(1):57-68 |
| abstractText | Previously, we showed that mice that overexpress the 5-HT(1A) receptor transiently from embryonic to perinatal stages show reduced anxiety and changes in brain serotonin turnover as adults. Here, we investigated the long-term effects of the temporary overexpression of the 5-HT(1A) receptor during early embryonic and perinatal development on the performance in two memory tasks. In the hole-board test mice that were homozygous for the transgene showed similar behavioral habituation but increased locomotion compared to heterozygous mice. In contrast water-maze performance of homozygous mice was impaired compared to heterozygous mice. These results suggest that a transient overexpression of 5-HT(1A) receptor during embryonic and perinatal development has detrimental effects on water-maze performance at adult stages. |
