| First Author | Ryan ZC | Year | 2014 |
| Journal | Biochem Biophys Res Commun | Volume | 448 |
| Issue | 1 | Pages | 83-8 |
| PubMed ID | 24780398 | Mgi Jnum | J:219447 |
| Mgi Id | MGI:5620844 | Doi | 10.1016/j.bbrc.2014.04.092 |
| Citation | Ryan ZC, et al. (2014) Enhanced prostacyclin formation and Wnt signaling in sclerostin deficient osteocytes and bone. Biochem Biophys Res Commun 448(1):83-8 |
| abstractText | We show that prostacyclin production is increased in bone and osteocytes from sclerostin (Sost) knockout mice which have greatly increased bone mass. The addition of prostacyclin or a prostacyclin analog to bone forming osteoblasts enhances differentiation and matrix mineralization of osteoblasts. The increase in prostacyclin synthesis is linked to increases in beta-catenin concentrations and activity as shown by enhanced binding of lymphoid enhancer factor, Lef1, to promoter elements within the prostacyclin synthase promoter. Blockade of Wnt signaling reduces prostacyclin production in osteocytes. Increased prostacyclin production by osteocytes from sclerostin deficient mice could potentially contribute to the increased bone formation seen in this condition. |
