| First Author | Noordegraaf M | Year | 2010 |
| Journal | J Invest Dermatol | Volume | 130 |
| Issue | 12 | Pages | 2752-9 |
| PubMed ID | 20703247 | Mgi Jnum | J:165825 |
| Mgi Id | MGI:4838505 | Doi | 10.1038/jid.2010.223 |
| Citation | Noordegraaf M, et al. (2010) Functional redundancy of langerhans cells and langerin(+) dermal dendritic cells in contact hypersensitivity. J Invest Dermatol 130(12):2752-9 |
| abstractText | The relative roles of Langerhans cells (LC), dermal dendritic cells (DC), and, in particular, the recently discovered Langerin(+) dermal DC subset in the induction and control of contact hypersensitivity (CHS) responses remain controversial. Using an inducible mouse model, in which LC and other Langerin(+) DC can be depleted by injection of diphtheria toxin, we previously reported impaired transport of topically applied antigen to draining lymph nodes and reduced CHS in the absence of all Langerin(+) skin DC. In this study, we demonstrate that mice with a selective depletion of LC exhibit attenuated CHS only upon sensitization with a low hapten dose but not with a high hapten dose. In contrast, when painting a higher concentration of hapten onto the skin, which leads to increased antigen dissemination into the dermis, CHS is still diminished in mice lacking all Langerin(+) skin DC. Taken together, these data suggest that the magnitude of a CHS reaction depends on the number of skin DC, which have access to the hapten, rather than on the presence or absence of a particular skin DC population. LC and (Langerin(+)) dermal DC thus seem to have a redundant function in regulating CHS. |
