| First Author | Bonefeld CM | Year | 2008 |
| Journal | J Immunol | Volume | 181 |
| Issue | 11 | Pages | 7786-99 |
| PubMed ID | 19017968 | Mgi Jnum | J:142387 |
| Mgi Id | MGI:3821443 | Doi | 10.4049/jimmunol.181.11.7786 |
| Citation | Bonefeld CM, et al. (2008) TCR down-regulation controls virus-specific CD8+ T cell responses. J Immunol 181(11):7786-99 |
| abstractText | The CD3gamma di-leucine-based motif plays a central role in TCR down-regulation. However, little is understood about the role of the CD3gamma di-leucine-based motif in physiological T cell responses. In this study, we show that the expansion in numbers of virus-specific CD8(+) T cells is impaired in mice with a mutated CD3gamma di-leucine-based motif. The CD3gamma mutation did not impair early TCR signaling, nor did it compromise recruitment or proliferation of virus-specific T cells, but it increased the apoptosis rate of the activated T cells by increasing down-regulation of the antiapoptotic molecule Bcl-2. This resulted in a 2-fold reduction in the clonal expansion of virus-specific CD8(+) T cells during the acute phase of vesicular stomatitis virus and lymphocytic choriomeningitis virus infections. These results identify an important role of CD3gamma-mediated TCR down-regulation in virus-specific CD8(+) T cell responses. |
