| First Author | Shrestha BR | Year | 2023 |
| Journal | Dev Cell | Volume | 58 |
| Issue | 4 | Pages | 306-319.e5 |
| PubMed ID | 36800995 | Mgi Jnum | J:333986 |
| Mgi Id | MGI:7443916 | Doi | 10.1016/j.devcel.2023.01.008 |
| Citation | Shrestha BR, et al. (2023) Runx1 controls auditory sensory neuron diversity in mice. Dev Cell 58(4):306-319.e5 |
| abstractText | Sound stimulus is encoded in mice by three molecularly and physiologically diverse subtypes of sensory neurons, called Ia, Ib, and Ic spiral ganglion neurons (SGNs). Here, we show that the transcription factor Runx1 controls SGN subtype composition in the murine cochlea. Runx1 is enriched in Ib/Ic precursors by late embryogenesis. Upon the loss of Runx1 from embryonic SGNs, more SGNs take on Ia rather than Ib or Ic identities. This conversion was more complete for genes linked to neuronal function than to connectivity. Accordingly, synapses in the Ib/Ic location acquired Ia properties. Suprathreshold SGN responses to sound were enhanced in Runx1(CKO) mice, confirming the expansion of neurons with Ia-like functional properties. Runx1 deletion after birth also redirected Ib/Ic SGNs toward Ia identity, indicating that SGN identities are plastic postnatally. Altogether, these findings show that diverse neuronal identities essential for normal auditory stimulus coding arise hierarchically and remain malleable during postnatal development. |
