| First Author | Khibnik LA | Year | 2014 |
| Journal | PLoS One | Volume | 9 |
| Issue | 8 | Pages | e104501 |
| PubMed ID | 25141172 | Mgi Jnum | J:223280 |
| Mgi Id | MGI:5648622 | Doi | 10.1371/journal.pone.0104501 |
| Citation | Khibnik LA, et al. (2014) A direct projection from mouse primary visual cortex to dorsomedial striatum. PLoS One 9(8):e104501 |
| abstractText | The mammalian striatum receives inputs from many cortical areas, but the existence of a direct axonal projection from the primary visual cortex (V1) is controversial. In this study we use anterograde and retrograde tracing techniques to demonstrate that V1 directly innervates a topographically defined longitudinal strip of dorsomedial striatum in mice. We find that this projection forms functional excitatory synapses with direct and indirect pathway striatal projection neurons (SPNs) and engages feed-forward inhibition onto these cells. Importantly, stimulation of V1 afferents is sufficient to evoke phasic firing in SPNs. These findings therefore identify a striatal region that is functionally innervated by V1 and suggest that early visual processing may play an important role in striatal-based behaviors. |
