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Allele : Cryge<t> crystallin, gamma E; total opacity and microphthalmia

Primary Identifier  MGI:1857598 Allele Type  Radiation induced
Gene  Cryge Inheritance Mode  Dominant
Strain of Origin  (102/El x C3H/El)F1 Is Recombinase  false
Is Wild Type  false
description 

With the discovery that the mutation is a nucleotide substitution, it has been suggested that CrygeCat2-t may have possibly been spontaneous instead of X-ray induced J:50319.

Phenotypic Similarity to Human Syndrome: Dominant Cataracts in heterozygous and homozygous mice mice (J:9528)

molecularNote  A C to G transversion at nucleotide position 432 in exon 3 of Cryge that creates a premature termination signal and results in a truncated protein after amino acid 143.
  • mutations:
  • Single point mutation
  • synonyms:
  • R-324,
  • Cat-2<t>,
  • R-324,
  • Cat2<t>,
  • Cat2<t>,
  • Cryge<Cat2-t>,
  • Cryge<Cat2-t>,
  • Cat-2<t>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

8 Publication categories