| First Author | Laprell L | Year | 2021 |
| Journal | J Neuroinflammation | Volume | 18 |
| Issue | 1 | Pages | 21 |
| PubMed ID | 33423699 | Mgi Jnum | J:351270 |
| Mgi Id | MGI:6803109 | Doi | 10.1186/s12974-020-02048-0 |
| Citation | Laprell L, et al. (2021) The role of microglia membrane potential in chemotaxis. J Neuroinflammation 18(1):21 |
| abstractText | Microglia react to danger signals by rapid and targeted extension of cellular processes towards the source of the signal. This positive chemotactic response is accompanied by a hyperpolarization of the microglia membrane. Here, we show that optogenetic depolarization of microglia has little effect on baseline motility, but significantly slows down the chemotactic response. Reducing the extracellular Ca(2+) concentration mimics the effect of optogenetic depolarization. As the membrane potential sets the driving force for Ca(2+) entry, hyperpolarization is an integral part of rapid stimulus-response coupling in microglia. Compared to typical excitable cells such as neurons, the sign of the activating response is inverted in microglia, leading to inhibition by depolarizing channelrhodopsins. |
