| First Author | He S | Year | 2022 |
| Journal | Neurobiol Dis | Volume | 174 |
| Pages | 105893 | PubMed ID | 36229006 |
| Mgi Jnum | J:352433 | Mgi Id | MGI:7366793 |
| Doi | 10.1016/j.nbd.2022.105893 | Citation | He S, et al. (2022) An NTS-CeA projection modulates depression-like behaviors in a mouse model of chronic pain. Neurobiol Dis 174:105893 |
| abstractText | Depressive symptoms comorbid with chronic pain are a common health problem, but the underlying neural circuit mechanisms remain elusive. Here, we identify a glutamatergic projection from the nucleus of the solitary tract (NTS) to the central nucleus of the amygdala (CeA) that mediates depression-like behaviors in a chemotherapy-induced neuropathic pain model. Inhibition or ablation of the glutamatergic NTS neurons alleviates depressive but not hypersensitive behaviors in these mice. The projected neurons form excitatory synapses with somatostatin-expressing neurons in the CeA. Silencing the NTS-CeA projection alleviates depressive but not hypersensitive behaviors, whereas activating the proection promotes depressive behaviors. In addition, in naive mice, activation of the NTS-CeA projection induces obvious depressive behaviors that can be blocked by silencing the CeA somatostatin-expressing neurons. Together, we reveal a modulatory role of the NTS and its glutamatergic projection to the CeA circuit in modulating depression-like behaviors comorbid to chronic pain. |
