| First Author | Naik AA | Year | 2021 |
| Journal | Prog Neurobiol | Volume | 200 |
| Pages | 101984 | PubMed ID | 33388373 |
| Mgi Jnum | J:355700 | Mgi Id | MGI:7751476 |
| Doi | 10.1016/j.pneurobio.2020.101984 | Citation | Naik AA, et al. (2021) Mechanism of seizure-induced retrograde amnesia. Prog Neurobiol 200:101984 |
| abstractText | Seizures cause retrograde amnesia, but underlying mechanisms are poorly understood. We tested whether seizure activated neuronal circuits overlap with spatial memory engram and whether seizures saturate LTP in engram cells. A seizure caused retrograde amnesia for spatial memory task. Spatial learning and a seizure caused cFos expression and synaptic plasticity overlapping set of neurons in the CA1 of the hippocampus. Recordings from learning-labeled CA1 pyramidal neurons showed potentiated synapses. Seizure-tagged neurons were also more excitable with larger rectifying excitatory postsynaptic currents than surrounding unlabeled neurons. These neurons had enlarged dendritic spines and saturated LTP. A seizure immediately after learning, reset the memory engram. Seizures cause retrograde amnesia through shared ensembles and mechanisms. |
