| First Author | Tien NW | Year | 2017 |
| Journal | Neuron | Volume | 94 |
| Issue | 3 | Pages | 656-665.e4 |
| PubMed ID | 28457596 | Mgi Jnum | J:253559 |
| Mgi Id | MGI:6109546 | Doi | 10.1016/j.neuron.2017.04.016 |
| Citation | Tien NW, et al. (2017) Homeostatic Plasticity Shapes Cell-Type-Specific Wiring in the Retina. Neuron 94(3):656-665.e4 |
| abstractText | Convergent input from different presynaptic partners shapes the responses of postsynaptic neurons. Whether developing postsynaptic neurons establish connections with each presynaptic partner independently or balance inputs to attain specific responses is unclear. Retinal ganglion cells (RGCs) receive convergent input from bipolar cell types with different contrast responses and temporal tuning. Here, using optogenetic activation and pharmacogenetic silencing, we found that type 6 bipolar (B6) cells dominate excitatory input to ONalpha-RGCs. We generated mice in which B6 cells were selectively removed from developing circuits (B6-DTA). In B6-DTA mice, ONalpha-RGCs adjusted connectivity with other bipolar cells in a cell-type-specific manner. They recruited new partners, increased synapses with some existing partners, and maintained constant input from others. Patch-clamp recordings revealed that anatomical rewiring precisely preserved contrast and temporal frequency response functions of ONalpha-RGCs, indicating that homeostatic plasticity shapes cell-type-specific wiring in the developing retina to stabilize visual information sent to the brain. |
