| First Author | Sippy T | Year | 2015 |
| Journal | Neuron | Volume | 88 |
| Issue | 2 | Pages | 298-305 |
| PubMed ID | 26439527 | Mgi Jnum | J:250395 |
| Mgi Id | MGI:6099263 | Doi | 10.1016/j.neuron.2015.08.039 |
| Citation | Sippy T, et al. (2015) Cell-Type-Specific Sensorimotor Processing in Striatal Projection Neurons during Goal-Directed Behavior. Neuron 88(2):298-305 |
| abstractText | Goal-directed sensorimotor transformation drives important aspects of mammalian behavior. The striatum is thought to play a key role in reward-based learning and action selection, receiving glutamatergic sensorimotor signals and dopaminergic reward signals. Here, we obtain whole-cell membrane potential recordings from the dorsolateral striatum of mice trained to lick a reward spout after a whisker deflection. Striatal projection neurons showed strong task-related modulation, with more depolarization and action potential firing on hit trials compared to misses. Direct pathway striatonigral neurons, but not indirect pathway striatopallidal neurons, exhibited a prominent early sensory response. Optogenetic stimulation of direct pathway striatonigral neurons, but not indirect pathway striatopallidal neurons, readily substituted for whisker stimulation evoking a licking response. Our data are consistent with direct pathway striatonigral neurons contributing a "go" signal for goal-directed sensorimotor transformation leading to action initiation. VIDEO ABSTRACT. |
