| First Author | Gupta B | Year | 2021 |
| Journal | Cell Rep | Volume | 36 |
| Issue | 8 | Pages | 109588 |
| PubMed ID | 34433050 | Mgi Jnum | J:337672 |
| Mgi Id | MGI:6764032 | Doi | 10.1016/j.celrep.2021.109588 |
| Citation | Gupta B, et al. (2021) The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus. Cell Rep 36(8):109588 |
| abstractText | Radial glia-like (RGL) stem cells persist in the adult mammalian hippocampus, where they generate new neurons and astrocytes throughout life. The process of adult neurogenesis is well documented, but cell-autonomous factors regulating neuronal and astroglial differentiation are incompletely understood. Here, we evaluate the functions of the transcription factor zinc-finger E-box binding homeobox 1 (ZEB1) in adult hippocampal RGL cells using a conditional-inducible mouse model. We find that ZEB1 is necessary for self-renewal of active RGL cells. Genetic deletion of Zeb1 causes a shift toward symmetric cell division that consumes the RGL cell and generates pro-neuronal progenies, resulting in an increase of newborn neurons and a decrease of newly generated astrocytes. We identify ZEB1 as positive regulator of the ets-domain transcription factor ETV5 that is critical for asymmetric division. |
