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Publication : Parallel processing of working memory and temporal information by distinct types of cortical projection neurons.

First Author  Bae JW Year  2021
Journal  Nat Commun Volume  12
Issue  1 Pages  4352
PubMed ID  34272368 Mgi Jnum  J:349583
Mgi Id  MGI:6725677 Doi  10.1038/s41467-021-24565-z
Citation  Bae JW, et al. (2021) Parallel processing of working memory and temporal information by distinct types of cortical projection neurons. Nat Commun 12(1):4352
abstractText  It is unclear how different types of cortical projection neurons work together to support diverse cortical functions. We examined the discharge characteristics and inactivation effects of intratelencephalic (IT) and pyramidal tract (PT) neurons-two major types of cortical excitatory neurons that project to cortical and subcortical structures, respectively-in the deep layer of the medial prefrontal cortex in mice performing a delayed response task. We found stronger target-dependent firing of IT than PT neurons during the delay period. We also found the inactivation of IT neurons, but not PT neurons, impairs behavioral performance. In contrast, PT neurons carry more temporal information than IT neurons during the delay period. Our results indicate a division of labor between IT and PT projection neurons in the prefrontal cortex for the maintenance of working memory and for tracking the passage of time, respectively.
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